Antibiotic resistance presents an incessant threat to our drug armamentarium that
necessitates novel approaches to therapy. Over the past several decades, investigation of …

Voriconazole, a second-generation triazole frequently used for the prophylaxis and
treatment of invasive fungal infections, undergoes complex metabolism mainly involving …

Objectives Vancomycin is a vital treatment option for patients suffering from critical
infections, and therapeutic drug monitoring is recommended. Bayesian forecasting is …

As protein binding of uremic toxins is not well understood, neither in chronic kidney disease
(CKD) progression, nor during a hemodialysis (HD) session, we studied protein binding in …

Aims The aim of the present study was to assess the pharmacokinetics of total and unbound
ceftriaxone in intensive care unit (ICU) patients and its protein binding characteristics …

Surprisingly, misinterpretation of the influence of hypoalbuminemia on pharmacokinetics
and the clinical effects of drugs seems to be a current problem, even though …

Optimization of antimicrobial dosing in accordance with pharmacokinetics/
pharmacodynamics targets can improve survival and clinical cure. Dosing regimens for …

In some patient groups, including critically ill patients, the pharmacokinetics of β-lactam
antibiotics may be profoundly disturbed due to pathophysiological changes in distribution …

Antimicrobial resistance is a major global health challenge. As few new efficacious
antibiotics will become available in the near future, peptide antibiotics continue to be major …

Background Therapeutic drug monitoring (TDM) is a tool to personalize and optimize dosing
by measuring the drug concentration and subsequently adjusting the dose to reach a target …