This review briefly describes the most common chronic inflammatory diseases in childhood,
such as cystic fibrosis (CF), inflammatory bowel diseases (IBDs), juvenile idiopathic arthritis …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel for
transport of chloride and bicarbonate anions. Functional roles of CFTR have been identified …

Despite enormous advances in translational biomedical research, there remains a growing
demand for improved animal models of human disease. This is particularly true for diseases …

Swine are increasingly studied as animal models of human disease. The anatomy, size,
longevity, physiology, immune system, and metabolism of swine are more like humans than …

There is an unmet need for artificial tissue to address current limitations with donor organs
and problems with donor site morbidity. Despite the success with sophisticated tissue …

Cystic fibrosis (CF) is the most common life-shortening autosomal recessive disorder in the
Caucasian population and occurs in many other ethnicities worldwide. The daily treatment …

In the era of combined antiretroviral therapy (cART), lung diseases such as chronic
bronchitis (CB) and chronic obstructive pulmonary disease (COPD) are common among …

Gene therapy provides a mutation‐independent approach to treat or even cure CF airway
disease. To develop a clinical candidate for CF gene therapy, a thorough examination of …

Deficient function in the anion channel cystic fibrosis (CF) transmembrane conductance
regulator is the fundamental cause for CF. This is a monogenic condition that causes lesions …

Ultrasound (US) is an ideal diagnostic tool for paediatric patients owning to its high spatial
and temporal resolution, realtime imaging, and lack of ionizing radiation and bedside …