Cancer stem cells (CSCs) are a small subpopulation of cells within a tumor that can both self‐
renew and differentiate into other cell types forming the heterogeneous tumor bulk. Since …

The history of drug development clearly shows the scale of painstaking effort leading to a
finished product–a highly biologically active agent that would be at the same time no or little …

Salinomycin (1) exhibits a large spectrum of biological activities including the capacity to
selectively eradicate cancer stem cells (CSC), making it and its derivatives promising …

The current paper provides a theoretical and experimental coupled study of synthesized N–
octanoyl glycine and N–oleoyl glycine. The derivatives were characterized using nuclear …

Polyether ionophore antibiotics (ionophores) represent a large group of more than 120 lipid-
soluble compounds that are widely used in veterinary medicine because of their significant …

Salinomycin, a polyether antibiotic used for treatment of coccidial disease in animal
husbandry, has demonstrated promising efficacy for treating different cancers. To enrich …

Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To
improve its potency and selectivity, an analog library of salinomycin was generated by site …

Cancer stem cells (CSC) have been shown to be refractory to conventional therapeutic
agents, can promote metastasis, and have been linked to cancer relapse. The natural …

To improve the druggability of salinomycin, a 20-epi-amino-20-deoxysalinomycin derivatives
library was synthesized with high efficacy from which a few salinomycin derivatives with high …

Several salinomycin-hydroxamic acid conjugates were designed and synthesized. Most
conjugates showed better antiproliferative activities than salinomycin in HT-29 colon cancer …