Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

This review covers recent literature from 2012-2019 concerning 170 marine natural products
and their semisynthetic analogues with strong anticancer biological activities. Reports that …

Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules.
While the interaction of paclitaxel with microtubules is well described, the lack of high …

Highlights•Dysregulation of microtubule dynamics triggers neurodegeneration and
neurotoxicity.•MTAs are able to restore MT dynamics and disease-related pathology in …

Tubulin, the microtubules and their dynamic behavior are amongst the most successful
antitumor, antifungal, antiparasitic, and herbicidal drug targets. Sulfonamides are exemplary …

Microtubules are cytoskeletal polymers of tubulin and composed of α-and β-tubulin
heterodimers, which are regarded as one of the most important, promising and successful …

A dual-purpose strategy aimed at enhancing the binding affinity for microtubules and
improving the water solubility of docetaxel led to the design and synthesis of a series of C-2 …

Microtubule‐stabilizing agents (MSAs) are widely used in chemotherapy. Using X‐ray
crystallography we elucidated the detailed binding modes of two potent MSAs,(+) …

It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin
activation is modulation of the structure of a switch element (the M-loop) from a disordered …

Covering: 2014–2019 We review recent progress on natural products that target cytoskeletal
components, including microtubules, actin, intermediate filaments, and septins and highlight …