The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being
evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the …

Background The prognosis of people with metastatic cutaneous melanoma, a skin cancer, is
generally poor. Recently, new classes of drugs (eg immune checkpoint inhibitors and small …

Clinical decisions in cancer rely on precisely assessing patient risk. To improve our ability to
identify the most aggressive malignancies, we constructed genome-wide survival models …

The past decades have seen tremendous developments with respect to “specific”
therapeutics that target key signaling molecules to conquer cancer. The key advancements …

Breast cancer is the most common malignancy in women worldwide and despite significant
advancements in detection, treatment, and management of cancer, it is still the leading …

The pharmaceutical industry is increasingly joining chemoinformatics in the search for the
development of new drugs to be used in the treatment of diseases. These computational …

Highlights•Phenotypic models can represent complex in vivo disease situations.•Target
deconvolution is a major roadblock for phenotypic screening.•In silico and in vitro …

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor that accounts for 2-4% of
all thyroid cancers. All inherited MTC and approximately 50% of sporadic cases are driven …

The protein kinase family contains many promising drug targets. Many kinase inhibitors
target the ATP-binding pocket, leading to approved drugs in past decades. Scaffold hop** …

Kinase inhibitors are crucial in cancer treatment, but drug resistance and side effects hinder
the development of effective drugs. To address these challenges, it is essential to analyze …