Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …

Homologous recombination (HR) is required for accurate chromosome segregation during
the first meiotic division and constitutes a key repair and tolerance pathway for complex DNA …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

The repair of DNA lesions that occur endogenously or in response to diverse genotoxic
stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways …

Protein modification by SUMO affects a wide range of protein substrates. Surprisingly,
although SUMO pathway mutants display strong phenotypes, the function of individual …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

With the discovery in the late 1980s that the DNA-repair gene RAD6 encodes a ubiquitin-
conjugating enzyme, it became clear that protein modification by ubiquitin conjugation has a …

Post-translational modification by Small Ubiquitin-like Modifier (SUMO) proteins regulates
numerous cellular processes. This modification involves the covalent and reversible …

Homologous recombination (HR) is crucial for maintaining genome integrity by repairing
DNA double-strand breaks (DSBs) and rescuing collapsed replication forks. In contrast …