Structure, function and evolution of three-finger toxins: mini proteins with multiple targets
Snake venoms are complex mixtures of pharmacologically active peptides and proteins.
These protein toxins belong to a small number of superfamilies of proteins. Three-finger …
These protein toxins belong to a small number of superfamilies of proteins. Three-finger …
[HTML][HTML] Snake and snail toxins acting on nicotinic acetylcholine receptors: fundamental aspects and medical applications
VI Tsetlin, F Hucho - FEBS letters, 2004 - Elsevier
This review covers recent data on interactions of nicotinic acetylcholine receptors (AChR)
with snake venom proteins (α-and κ-neurotoxins,'weak'toxins recently shown to act on …
with snake venom proteins (α-and κ-neurotoxins,'weak'toxins recently shown to act on …
Venomics, lethality and neutralization of Naja kaouthia (monocled cobra) venoms from three different geographical regions of Southeast Asia
Previous studies showed that venoms of the monocled cobra, Naja kaouthia from Thailand
and Malaysia are substantially different in their median lethal doses. The intraspecific venom …
and Malaysia are substantially different in their median lethal doses. The intraspecific venom …
Venom Proteomics of Indonesian King Cobra, Ophiophagus hannah: Integrating Top-Down and Bottom-Up Approaches
D Petras, P Heiss, RD Süssmuth… - Journal of proteome …, 2015 - ACS Publications
We report on the first application of top-down mass spectrometry in snake venomics. De
novo sequence tags generated by, and ProSight Lite supported analysis of, combined …
novo sequence tags generated by, and ProSight Lite supported analysis of, combined …
[PDF][PDF] Molecular moulds with multiple missions: functional sites in three-finger toxins.
RM Kini - Clinical & Experimental Pharmacology & Physiology, 2002 - kingsnake.com
Snake venoms are complex mixtures of pharmacologically active peptides and proteins. 2.
These protein toxins belong to a small number of superfamilies of proteins. The present …
These protein toxins belong to a small number of superfamilies of proteins. The present …
Venomics of Naja sputatrix, the Javan spitting cobra: A short neurotoxin-driven venom needing improved antivenom neutralization
The venom proteome of Naja sputatrix (Javan spitting cobra) was elucidated through
reverse-phase HPLC, nano-ESI-LCMS/MS and data mining. A total of 97 distinct protein …
reverse-phase HPLC, nano-ESI-LCMS/MS and data mining. A total of 97 distinct protein …
Quantitative proteomics of Naja annulifera (sub-Saharan snouted cobra) venom and neutralization activities of two antivenoms in Africa
Envenomation by Naja annulifera (snouted cobra), a non-spitting African cobra, can result in
local tissue damage and fatal paralysis but a species-specific antivenom treatment is …
local tissue damage and fatal paralysis but a species-specific antivenom treatment is …
“Weak toxin” from Naja kaouthia is a nontoxic antagonist of α7 and muscle-type nicotinic acetylcholine receptors
YN Utkin, VV Kukhtina, EV Kryukova, F Chiodini… - Journal of Biological …, 2001 - ASBMB
A novel" weak toxin"(WTX) from Naja kaouthia snake venom competes with [125 I] α-
bungarotoxin for binding to the membrane-bound Torpedo californica acetylcholine receptor …
bungarotoxin for binding to the membrane-bound Torpedo californica acetylcholine receptor …
Non-conventional toxins from Elapid venoms
Non-conventional toxins constitute a poorly characterized class of three-finger toxins
isolated exclusively from Elapidae venoms. These toxins are monomers of 62–68 amino …
isolated exclusively from Elapidae venoms. These toxins are monomers of 62–68 amino …
Comparative venom gland transcriptomics of Naja kaouthia (monocled cobra) from Malaysia and Thailand: elucidating geographical venom variation and insights into …
Background The monocled cobra (Naja kaouthia) is a medically important venomous snake
in Southeast Asia. Its venom has been shown to vary geographically in relation to venom …
in Southeast Asia. Its venom has been shown to vary geographically in relation to venom …