Cellular and Molecular Mechanisms Regulating Retinal Synapse Development
Synapse formation within the retinal circuit ensures that distinct neuronal types can
communicate efficiently to process visual signals. Synapses thus form the core of the visual …
communicate efficiently to process visual signals. Synapses thus form the core of the visual …
Beyond the ligand: extracellular and transcellular G protein–coupled receptor complexes in physiology and pharmacology
G protein–coupled receptors (GPCRs) remain one of the most successful targets of US Food
and Drug Administration–approved drugs. GPCR research has predominantly focused on …
and Drug Administration–approved drugs. GPCR research has predominantly focused on …
Targeting ON-bipolar cells by AAV gene therapy stably reverses LRIT3-congenital stationary night blindness
K Miyadera, E Santana, K Roszak… - Proceedings of the …, 2022 - National Acad Sciences
Adeno-associated virus (AAV)–based gene therapies aimed at curing inherited retinal
diseases to date have typically focused on photoreceptors and retinal pigmented epithelia …
diseases to date have typically focused on photoreceptors and retinal pigmented epithelia …
[HTML][HTML] Development and maintenance of vision's first synapse
Synapses in the outer retina are the first information relay points in vision. Here,
photoreceptors form synapses onto two types of interneurons, bipolar cells and horizontal …
photoreceptors form synapses onto two types of interneurons, bipolar cells and horizontal …
Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia
B Wilmet, J Callebert, R Duvoisin, R Goulet… - International journal of …, 2022 - mdpi.com
Mutations in GPR179 are one of the most common causes of autosomal recessive complete
congenital stationary night blindness (cCSNB). This retinal disease is characterized in …
congenital stationary night blindness (cCSNB). This retinal disease is characterized in …
Presynaptic expression of LRIT3 transsynaptically organizes the postsynaptic glutamate signaling complex containing TRPM1
Throughout the CNS, interactions between pre-and postsynaptic adhesion molecules
establish normal synaptic structure and function. Leucine-rich repeat (LRR) domain …
establish normal synaptic structure and function. Leucine-rich repeat (LRR) domain …
Lrit1, a retinal transmembrane protein, regulates selective synapse formation in cone photoreceptor cells and visual acuity
A Ueno, Y Omori, Y Sugita, S Watanabe, T Chaya… - Cell reports, 2018 - cell.com
In the vertebrate retina, cone photoreceptors play crucial roles in photopic vision by
transmitting light-evoked signals to ON-and/or OFF-bipolar cells. However, the mechanisms …
transmitting light-evoked signals to ON-and/or OFF-bipolar cells. However, the mechanisms …
Ribbon synapses and retinal disease
CE Frederick, D Zenisek - International Journal of Molecular Sciences, 2023 - mdpi.com
Synaptic ribbons are presynaptic protein complexes that are believed to be important for the
transmission of sensory information in the visual system. Ribbons are selectively associated …
transmission of sensory information in the visual system. Ribbons are selectively associated …
Molecular mechanisms underlying selective synapse formation of vertebrate retinal photoreceptor cells
T Furukawa, A Ueno, Y Omori - Cellular and Molecular Life Sciences, 2020 - Springer
In vertebrate central nervous systems (CNSs), highly diverse neurons are selectively
connected via synapses, which are essential for building an intricate neural network. The …
connected via synapses, which are essential for building an intricate neural network. The …
Restoration of mGluR6 localization following AAV-mediated delivery in a mouse model of congenital stationary night blindness
Purpose: Complete congenital stationary night blindness (cCSNB) is an incurable inherited
retinal disorder characterized by an ON-bipolar cell (ON-BC) defect. GRM6 mutations are …
retinal disorder characterized by an ON-bipolar cell (ON-BC) defect. GRM6 mutations are …