Safety and side effects of the acne drug, oral isotretinoin

A Charakida, PE Mouser, AC Chu - Expert opinion on drug safety, 2004‏ - Taylor & Francis
Isotretinoin is a very effective medication for the treatment of severe recalcitrant acne.
However, its use is associated with many side effects, some of which can be very serious …

Safety issues in isotretinoin therapy.

N Hanson, S Leachman - Seminars in cutaneous medicine and …, 2001‏ - europepmc.org
Isotretinoin (Accutane, Roche Laboratories Inc, Nutley, NJ) is an important drug, not only for
the treatment of severe acne, but also for other diagnoses and in chemoprevention settings …

Retinoic acid signaling at sites of plasticity in the mature central nervous system

G Thompson Haskell, TM Maynard… - Journal of …, 2002‏ - Wiley Online Library
We used transgenic reporter mice to determine whether brain regions that respond to
retinoic acid (RA) during development do so in maturity. We focused on two prominent sites …

Neuromuscular adverse effects associated with systemic retinoid dermatotherapy: monitoring and treatment algorithm for clinicians

E Chroni, A Monastirli, D Tsambaos - Drug safety, 2010‏ - Springer
Although neuromuscular adverse effects represent significant clinical manifestations of
hypervitaminosis A syndrome, surprisingly little attention has been paid to the potential …

Section Review: Retinoids: Biological function and use in the treatment of dermatological diseases: Pulmonary-allergy, dermatological, gastrointestinal & arthritis

MF Boehm, RA Heyman, S Patel, RB Stein… - Expert Opinion on …, 1995‏ - Taylor & Francis
Retinoids have increasingly gained acceptance for single agent or adjuvant therapy to treat
dermatological diseases such as acne, photoageing, cutaneous neoplasia, psoriasis …

Assessment of auditory function and lipid levels in patients receiving oral isotretinoin (13-cis retinoid) therapy for acne vulgaris

M Yaldiz, A Kara, M Güven, B Solak, R Kara… - … in Dermatology and …, 2020‏ - termedia.pl
Aim The purpose of this prospective study is to investigate the effect of oral isotretinoin
therapy on auditory function using pure tone audiometry (PTA) and distortion product …

Brainstem auditory evoked potentials with the use of acoustic clicks and complex verbal sounds in young adults with learning disabilities

SN Kouni, S Giannopoulos, N Ziavra… - American journal of …, 2013‏ - Elsevier
Purpose and background Acoustic signals are transmitted through the external and middle
ear mechanically to the cochlea where they are transduced into electrical impulse for further …

Evaluation of retinal nerve fiber layer changes with oral isotretinoin treatment

BH Kaptı, G Aslan, MA Yavruoğlu - Ophthalmology and Therapy, 2013‏ - Springer
Introduction Central nervous system toxicity is a well-known side effect of isotretinoin
treatment. The aim of this study was to establish the effects of isotretinoin on retinal nerve …

Neurological and neurophysiological effects of oral isotretinoin: a prospective investigation using auditory and visual evoked potentials

K Aydogan, OF Turan, S Onart, B Yazici… - European Journal of …, 2008‏ - jle.com
Over the last decade, accumulating evidence has indicated that retinoids may be capable of
affecting the development, differentiation and function of nervous tissue. The purpose of the …

Brainstem auditory evoked potentials in patients with ischemic heart disease

DG Karamitsos, NG Kounis, GM Zavras… - The …, 1996‏ - Wiley Online Library
The authors of this study used the method of increased stimulus rate on brainstem auditory
evoked potentials (BAEPs) in 30 patients with ischemic heart disease (IHD) and in an equal …