Ginsenosides are a special group of triterpenoid saponins that can be classified into two
groups by the skeleton of their aglycones, namely dammarane‐and oleanane‐type …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Gut microbiota plays a key role in obesity and non-alcoholic fatty liver disease (NAFLD), so
synbiotics could be a therapeutic alternative. We aim to evaluate a nutritional intervention …

Nuclear receptors (NRs) regulate transcription in response to ligand binding and NR
modulation allows pharmacological control of gene expression. Although some NRs are …

Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …

PPARγ (peroxisome proliferator activated receptor γ) is a ligand activated transcription factor
of the nuclear receptor superfamily that controls the expression of a variety of genes …

Peroxisome proliferator-activated receptors (PPARs) compose a family of nuclear receptors
that mediate the effects of lipidic ligands at the transcriptional level. In this review, we …

Binding to helix 12 of the ligand-binding domain of PPARγ is required for full agonist activity.
Previously, the degree of stabilization of the activation function 2 (AF-2) surface was thought …

The ability of pollutants to affect human health is a major concern, justified by the wide
demonstration that reproductive functions are altered by endocrine disrupting chemicals …

Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ
to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these …