Detection and analysis of chiral molecules as disease biomarkers

Y Liu, Z Wu, DW Armstrong, H Wolosker… - Nature Reviews …, 2023 - nature.com
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Glutamate hypothesis in schizophrenia

Y Uno, JT Coyle - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an
individual's life and on society. Thus, develo** more effective therapeutic interventions is …

Dopamine and glutamate in schizophrenia: biology, symptoms and treatment

RA McCutcheon, JH Krystal, OD Howes - World Psychiatry, 2020 - Wiley Online Library
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …

Economics and mental health: the current scenario

M Knapp, G Wong - World Psychiatry, 2020 - Wiley Online Library
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …

Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia

P Steullet, JH Cabungcal, J Coyle, M Didriksen… - Molecular …, 2017 - nature.com
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper
excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity …

The NMDA receptor and schizophrenia: from pathophysiology to treatment

DT Balu - Advances in pharmacology, 2016 - Elsevier
Schizophrenia is a severe mental illness that affects almost 1% of the population worldwide.
Even though the etiology of schizophrenia is uncertain, it is believed to be a …

Transport mechanism and pharmacology of the human GlyT1

Y Wei, R Li, Y Meng, T Hu, J Zhao, Y Gao, Q Bai, N Li… - Cell, 2024 - cell.com
Summary The glycine transporter 1 (GlyT1) plays a crucial role in the regulation of both
inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft …

Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia

SA Buck, M Quincy Erickson-Oberg, RW Logan… - Molecular …, 2022 - nature.com
Dopamine (DA) and glutamate neurotransmission are strongly implicated in schizophrenia
pathophysiology. While most studies focus on contributions of neurons that release only DA …

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

GE Hardingham, KQ Do - Nature Reviews Neuroscience, 2016 - nature.com
Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …

The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies

W Hu, ML MacDonald, DE Elswick… - Annals of the New York …, 2015 - Wiley Online Library
A number of studies have indicated that antagonists of the N‐methyl‐d‐aspartate subtypes
of glutamate receptors can cause schizophrenia‐like symptoms in healthy individuals and …