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Detection and analysis of chiral molecules as disease biomarkers
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …
Glutamate hypothesis in schizophrenia
Y Uno, JT Coyle - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an
individual's life and on society. Thus, develo** more effective therapeutic interventions is …
individual's life and on society. Thus, develo** more effective therapeutic interventions is …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
P Steullet, JH Cabungcal, J Coyle, M Didriksen… - Molecular …, 2017 - nature.com
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper
excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity …
excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity …
The NMDA receptor and schizophrenia: from pathophysiology to treatment
DT Balu - Advances in pharmacology, 2016 - Elsevier
Schizophrenia is a severe mental illness that affects almost 1% of the population worldwide.
Even though the etiology of schizophrenia is uncertain, it is believed to be a …
Even though the etiology of schizophrenia is uncertain, it is believed to be a …
Transport mechanism and pharmacology of the human GlyT1
Y Wei, R Li, Y Meng, T Hu, J Zhao, Y Gao, Q Bai, N Li… - Cell, 2024 - cell.com
Summary The glycine transporter 1 (GlyT1) plays a crucial role in the regulation of both
inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft …
inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft …
Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia
Dopamine (DA) and glutamate neurotransmission are strongly implicated in schizophrenia
pathophysiology. While most studies focus on contributions of neurons that release only DA …
pathophysiology. While most studies focus on contributions of neurons that release only DA …
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
Molecular, genetic and pathological evidence suggests that deficits in GABAergic
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through …
The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies
A number of studies have indicated that antagonists of the N‐methyl‐d‐aspartate subtypes
of glutamate receptors can cause schizophrenia‐like symptoms in healthy individuals and …
of glutamate receptors can cause schizophrenia‐like symptoms in healthy individuals and …