Advances in systems and synthetic biology have propelled the construction of reduced
bacterial genomes. Genome reduction was initially focused on exploring properties of …

In order to decrease carbon emissions and negative environmental impacts of various
pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the …

A transition toward sustainable bio-based chemical production is important for green growth.
However, productivity and yield frequently decrease as large-scale microbial fermentation …

With a world market of more than four million tons per year, l-amino acids are among the
most important products in industrial biotechnology. The recent years have seen a …

The l-aspartate amino acids (AFAAs) are constituted of l-aspartate, l-lysine, l-methionine, l-
threonine and l-isoleucine. Except for l-aspartate, AFAAs are essential amino acids that …

Escherichia coli is generally used as model bacteria to define microbial cell factories for
many products and to investigate regulation mechanisms. E. coli exhibits phospholipids …

Branched-chain amino acids (BCAAs) such as L-valine, L-leucine, and L-isoleucine are
widely used in food and feed. To comply with sustainable development goals, commercial …

Microbial fermentation processes are expected to play an important role in reducing
dependence on fossil-based raw materials for the production of everyday chemicals. In …

Redox balance plays an important role in the production of enzymes, pharmaceuticals, and
chemicals. To meet the demands of industrial production, it is desirable that microbes …

The biotechnological production of amino acids occurs at the million-ton scale and annually
about 6 million tons of l-glutamate and l-lysine are produced by Escherichia coli and …