To execute the intricate process of development, cells coordinate across tissues and organs
to determine where each cell divides and differentiates. This coordination requires complex …

Radial glia-like neural stem cells (RGLs) in the dentate gyrus subregion of the hippocampus
give rise to dentate granule cells (DGCs) and astrocytes throughout life, a process referred …

During embryogenesis tissue layers undergo morphogenetic flow rearranging and folding
into specific shapes. While developmental biology has identified key genes and local …

Organ architecture is often composed of multiple laminar tissues arranged in concentric
layers. During morphogenesis, the initial geometry of visceral organs undergoes a …

Regulation of stem cells requires coordination of the cells that make up the stem cell niche.
Here, we describe a mechanism that allows communication between niche cells to …

The presence of a wound triggers surrounding cells to initiate repair mechanisms, but it is
not clear how cells initially detect wounds. In epithelial cells, the earliest known wound …

Abstract Background Vitamin C (VC) is an indispensable antioxidant and co-factor for
optimal function and development of eukaryotic cells. In animals, VC can be synthesized by …

Stem cell homeostasis requires coordinated fate decisions among stem cells that are often
widely distributed within a tissue at varying distances from their stem cell niche. This …

Mechanosensitive Piezo channels regulate cell division, cell extrusion, and cell death.
However, systems-level functions of Piezo in regulating organogenesis remain poorly …

Self-referential cellular homeostasis is maintained by the measured assessment of both
internal status and external conditions based within an integrated cellular information field …