Regulator of G-protein signaling (RGS) proteins in cancer biology
The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional
proteins that regulate cellular signaling events downstream of G-protein coupled receptors …
proteins that regulate cellular signaling events downstream of G-protein coupled receptors …
Mammalian RGS proteins: multifunctional regulators of cellular signalling
GB Willars - Seminars in cell & developmental biology, 2006 - Elsevier
Regulators of G-protein signalling (RGS) proteins are a large and diverse family initially
identified as GTPase activating proteins (GAPs) of heterotrimeric G-protein Gα-subunits. At …
identified as GTPase activating proteins (GAPs) of heterotrimeric G-protein Gα-subunits. At …
RGS6 suppresses TGF-β-induced epithelial–mesenchymal transition in non-small cell lung cancers via a novel mechanism dependent on its interaction with SMAD4
Regulator of G-protein signaling 6 (RGS6) is a newly discovered tumor suppressor that has
been shown to be protective in development of various cancers such as breast cancer and …
been shown to be protective in development of various cancers such as breast cancer and …
Clonal evolution of high‐grade serous ovarian carcinoma from primary to recurrent disease
High‐grade serous carcinoma (HGSC) is the most common and fatal form of ovarian cancer.
While most tumours are highly sensitive to cytoreductive surgery and platinum‐and taxane …
While most tumours are highly sensitive to cytoreductive surgery and platinum‐and taxane …
Genetic analysis of rare human variants of regulators of G protein signaling proteins and their role in human physiology and disease
Regulators of G protein signaling (RGS) proteins modulate the physiologic actions of many
neurotransmitters, hormones, and other signaling molecules. Human RGS proteins …
neurotransmitters, hormones, and other signaling molecules. Human RGS proteins …
RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway
We have identified RGS17 as a commonly induced gene in lung and prostate tumors.
Through microarray and gene expression analysis, we show that expression of RGS17 is up …
Through microarray and gene expression analysis, we show that expression of RGS17 is up …
Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics
G-Protein-coupled receptors (GPCRs) signal through G protein α and βγ subunit families to
regulate a wide range of physiological and pathophysiological processes. As such, GPCRs …
regulate a wide range of physiological and pathophysiological processes. As such, GPCRs …
Gene-environment interaction effects on the development of immune responses in the 1st year of life
Asthma is a common disease that results from both genetic and environmental risk factors.
Children attending day care in the 1st year of life have lower risks for develo** asthma …
Children attending day care in the 1st year of life have lower risks for develo** asthma …
Fine Map** of Chromosome 6q23-25 Region in Familial Lung Cancer Families Reveals RGS17 as a Likely Candidate Gene
Purpose: We have previously mapped a major susceptibility locus influencing familial lung
cancer risk to chromosome 6q23-25. However, the causal gene at this locus remains …
cancer risk to chromosome 6q23-25. However, the causal gene at this locus remains …
Regulator of G protein signaling 6 mediates doxorubicin-induced ATM and p53 activation by a reactive oxygen species–dependent mechanism
J Huang, J Yang, B Maity, D Mayuzumi… - Cancer …, 2011 - aacrjournals.org
Doxorubicin (DXR), among the most widely used cancer chemotherapy agents, promotes
cancer cell death via activation of ataxia telangiectasia mutated (ATM) and the resultant …
cancer cell death via activation of ataxia telangiectasia mutated (ATM) and the resultant …