Type I interferon and the Spectrum of susceptibility to viral infection and autoimmune disease: a shared genomic signature
Type I interferons (IFN-I) and their cognate receptor, the IFNAR1/2 heterodimer, are critical
components of the innate immune system in humans. They have been widely explored in …
components of the innate immune system in humans. They have been widely explored in …
Antibody and Cell-Based Therapies against Virus-Induced Cancers in the Context of HIV/AIDS
Infectious agents, notably viruses, can cause or increase the risk of cancer occurrences.
These agents often disrupt normal cellular functions, promote uncontrolled proliferation and …
These agents often disrupt normal cellular functions, promote uncontrolled proliferation and …
CD56-negative NK cells: Frequency in peripheral blood, expansion during HIV-1 infection, functional capacity, and KIR expression
Human NK cells are usually defined as CD3-CD56+ lymphocytes. However, a CD56-CD16+
(CD56neg) lymphocyte population that displays NK-associated markers expands during …
(CD56neg) lymphocyte population that displays NK-associated markers expands during …
Deep phenotypic analysis of blood and lymphoid T and NK cells from HIV+ controllers and ART-suppressed individuals
T and natural killer (NK) cells are effector cells with key roles in anti-HIV immunity, including
in lymphoid tissues, the major site of HIV persistence. However, little is known about the …
in lymphoid tissues, the major site of HIV persistence. However, little is known about the …
NK cells from Men Who Have Sex with Men at high risk for HIV-1 infection exhibit higher effector capacity
Despite being under constant exposure to HIV-1, some individuals do not show serological
or clinical evidence of infection and are known as HESN (HIV-Exposed Seronegative) …
or clinical evidence of infection and are known as HESN (HIV-Exposed Seronegative) …
Harnessing immune cells to eliminate HIV reservoirs
P Grasberger, AR Sondrini… - Current Opinion in HIV …, 2024 - journals.lww.com
Several studies have shown promise in many preclinical models of disease, including
simian immunodeficiency virus (SIV)/SHIV infection in nonhuman primates and HIV infection …
simian immunodeficiency virus (SIV)/SHIV infection in nonhuman primates and HIV infection …
Natural killer cells in immunotherapy: are we nearly there?
M Bachiller, AM Battram, L Perez-Amill… - Cancers, 2020 - mdpi.com
Simple Summary Here, we review the last pre-clinical and clinical studies published in the
last five years where natural killer (NK) cells have been administered as an immunotherapy …
last five years where natural killer (NK) cells have been administered as an immunotherapy …
The CD56−CD16+ NK cell subset in chronic infections
ATH Cocker, LA Guethlein… - Biochemical Society …, 2023 - portlandpress.com
Long-term human diseases can shape the immune system, and natural killer (NK) cells have
been documented to differentiate into distinct subsets specifically associated with chronic …
been documented to differentiate into distinct subsets specifically associated with chronic …
Natural killer cell receptors and ligands are associated with markers of HIV-1 persistence in chronically infected ART suppressed patients
GT Ivison, E Vendrame, GJ Martínez-Colón… - Frontiers in Cellular …, 2022 - frontiersin.org
The latent HIV-1 reservoir represents a major barrier to achieving a long-term antiretroviral
therapy (ART)-free remission or cure for HIV-1. Natural Killer (NK) cells are innate immune …
therapy (ART)-free remission or cure for HIV-1. Natural Killer (NK) cells are innate immune …
CytoGLMM: conditional differential analysis for flow and mass cytometry experiments
Background Flow and mass cytometry are important modern immunology tools for
measuring expression levels of multiple proteins on single cells. The goal is to better …
measuring expression levels of multiple proteins on single cells. The goal is to better …