Type I interferons (IFN-I) and their cognate receptor, the IFNAR1/2 heterodimer, are critical
components of the innate immune system in humans. They have been widely explored in …

Several studies have shown promise in many preclinical models of disease, including
simian immunodeficiency virus (SIV)/SHIV infection in nonhuman primates and HIV infection …

Human NK cells are usually defined as CD3-CD56+ lymphocytes. However, a CD56-CD16+
(CD56neg) lymphocyte population that displays NK-associated markers expands during …

T and natural killer (NK) cells are effector cells with key roles in anti-HIV immunity, including
in lymphoid tissues, the major site of HIV persistence. However, little is known about the …

Simple Summary Here, we review the last pre-clinical and clinical studies published in the
last five years where natural killer (NK) cells have been administered as an immunotherapy …

Long-term human diseases can shape the immune system, and natural killer (NK) cells have
been documented to differentiate into distinct subsets specifically associated with chronic …

Background Flow and mass cytometry are important modern immunology tools for
measuring expression levels of multiple proteins on single cells. The goal is to better …

The latent HIV-1 reservoir represents a major barrier to achieving a long-term antiretroviral
therapy (ART)-free remission or cure for HIV-1. Natural Killer (NK) cells are innate immune …

Infectious agents, notably viruses, can cause or increase the risk of cancer occurrences.
These agents often disrupt normal cellular functions, promote uncontrolled proliferation and …

Immunological correlates of natural resistance to HIV have been identified in HIV-exposed
seronegative (HESN) individuals and include a low-inflammatory genital mucosal status …