The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …

Manipulation of DNA by CRISPR-Cas enzymes requires the recognition of a protospacer-
adjacent motif (PAM), limiting target site recognition to a subset of sequences. To remove …

Background Romosozumab, a monoclonal antibody that binds sclerostin, increases bone
formation and decreases bone resorption. Methods We enrolled 7180 postmenopausal …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent …

Osteoporosis is a common disease characterised by a systemic impairment of bone mass
and microarchitecture that results in fragility fractures. With an ageing population, the …

Bone homeostasis depends on the resorption of bones by osteoclasts and formation of
bones by the osteoblasts. Imbalance of this tightly coupled process can cause diseases …

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

The last decade has provided a virtual explosion of data on the molecular biology and
function of osteocytes. Far from being the “passive placeholder in bone,” this cell has been …

Background Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The
monoclonal antibody romosozumab binds to sclerostin and increases bone formation …