The assessment of pain, distress and suffering, as well as evaluation of the efficacy of stress-
reduction strategies, is crucial in animal experimentation but can be challenging in …

Animal models provide preclinical tools to investigate the causal role of genetic mutations
and environmental factors in the etiology of autism spectrum disorder (ASD). Knockout and …

Compromised placental function or premature loss has been linked to diverse
neurodevelopmental disorders. Here we show that placenta allopregnanolone (ALLO), a …

More than a hundred de novo single gene mutations and copy‐number variants have been
implicated in autism, each occurring in a small subset of cases. Mutant mouse models with …

Autism is a behaviourally defined disorder including attenuated or abnormal social
interaction and communication, as well as aberrant repetitive behaviour, with symptoms …

Synaptopathies are a class of neurodevelopmental disorders caused by modification in
genes coding for synaptic proteins. These proteins oversee the process of …

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder with complex
symptoms and unclear, multi-factorial pathogenesis. Animal (rodent) models of ASD-like …

Autism spectrum disorder (ASD) is associated, in addition to complex genetic factors, with a
variety of prenatal, perinatal and postnatal etiologies. We discuss the known animal models …

In order to understand the consequences of the mutation on behavioral and biological
phenotypes relevant to autism, mutations in many of the risk genes for autism spectrum …

The underlying cellular mechanisms of catatonia, an executive “psychomotor” syndrome that
is observed across neuropsychiatric diseases, have remained obscure. In humans and …