High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Antioxidant and oxidative stress: a mutual interplay in age-related diseases

BL Tan, ME Norhaizan, WPP Liew… - Frontiers in …, 2018 - frontiersin.org
Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

Targeting cancer vulnerabilities with high-dose vitamin C

B Ngo, JM Van Riper, LC Cantley, J Yun - Nature Reviews Cancer, 2019 - nature.com
Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier… - Science, 2015 - science.org
More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations
and are often refractory to approved targeted therapies. We found that cultured human CRC …

[HTML][HTML] Role of vitamin C in skin diseases

K Wang, H Jiang, W Li, M Qiang, T Dong… - Frontiers in physiology, 2018 - frontiersin.org
Vitamin C (ascorbic acid) plays an important role in maintaining skin health and can promote
the differentiation of keratinocytes and decrease melanin synthesis, leading to antioxidant …

Nuclear and cytoplasmic functions of vitamin C

A Zhitkovich - Chemical research in toxicology, 2020 - ACS Publications
Vitamin C (ascorbic acid) is a water-soluble antioxidant and a cofactor for a large number of
enzymes. It is present in all tissues and especially abundant in corneal epithelium, stem …

Understanding the therapeutic potential of ascorbic acid in the battle to overcome cancer

J Reang, PC Sharma, VK Thakur, J Majeed - Biomolecules, 2021 - mdpi.com
Cancer, a fatal disease, is also one of the main causes of death worldwide. Despite various
developments to prevent and treat cancer, the side effects of anticancer drugs remain a …

High-dose vitamin C for cancer therapy

A Mussa, RA Mohd Idris, N Ahmed, S Ahmad… - Pharmaceuticals, 2022 - mdpi.com
In recent years, the idea that Vitamin C (Vit-C) could be utilized as a form of anti-cancer
therapy has generated many contradictory arguments. Recent insights into the physiological …

Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation

D Mastrangelo, E Pelosi, G Castelli, F Lo-Coco… - Blood Cells, Molecules …, 2018 - Elsevier
Abstract Vitamin C (Vit C or Ascorbate) is essential for many fundamental biochemical
processes. Vit C is an essential nutrient with redox functions at normal physiologic …

[HTML][HTML] PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells

S Phadngam, A Castiglioni, A Ferraresi, F Morani… - Oncotarget, 2016 - ncbi.nlm.nih.gov
GLUT1 is the facilitative transporter playing the major role in the internalization of glucose.
Basally, GLUT1 resides on vesicles located in a para-golgian area, and is translocated onto …