High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer
F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …
agent when administered intravenously and in high doses (high-dose IVC). Early phase …
Antioxidant and oxidative stress: a mutual interplay in age-related diseases
Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …
positively linked to cognitive and biological degeneration such as physical frailty …
Targeting cancer vulnerabilities with high-dose vitamin C
Over the past century, the notion that vitamin C can be used to treat cancer has generated
much controversy. However, new knowledge regarding the pharmacokinetic properties of …
much controversy. However, new knowledge regarding the pharmacokinetic properties of …
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations
and are often refractory to approved targeted therapies. We found that cultured human CRC …
and are often refractory to approved targeted therapies. We found that cultured human CRC …
[HTML][HTML] Role of vitamin C in skin diseases
K Wang, H Jiang, W Li, M Qiang, T Dong… - Frontiers in physiology, 2018 - frontiersin.org
Vitamin C (ascorbic acid) plays an important role in maintaining skin health and can promote
the differentiation of keratinocytes and decrease melanin synthesis, leading to antioxidant …
the differentiation of keratinocytes and decrease melanin synthesis, leading to antioxidant …
Nuclear and cytoplasmic functions of vitamin C
A Zhitkovich - Chemical research in toxicology, 2020 - ACS Publications
Vitamin C (ascorbic acid) is a water-soluble antioxidant and a cofactor for a large number of
enzymes. It is present in all tissues and especially abundant in corneal epithelium, stem …
enzymes. It is present in all tissues and especially abundant in corneal epithelium, stem …
Understanding the therapeutic potential of ascorbic acid in the battle to overcome cancer
J Reang, PC Sharma, VK Thakur, J Majeed - Biomolecules, 2021 - mdpi.com
Cancer, a fatal disease, is also one of the main causes of death worldwide. Despite various
developments to prevent and treat cancer, the side effects of anticancer drugs remain a …
developments to prevent and treat cancer, the side effects of anticancer drugs remain a …
High-dose vitamin C for cancer therapy
In recent years, the idea that Vitamin C (Vit-C) could be utilized as a form of anti-cancer
therapy has generated many contradictory arguments. Recent insights into the physiological …
therapy has generated many contradictory arguments. Recent insights into the physiological …
Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation
Abstract Vitamin C (Vit C or Ascorbate) is essential for many fundamental biochemical
processes. Vit C is an essential nutrient with redox functions at normal physiologic …
processes. Vit C is an essential nutrient with redox functions at normal physiologic …
[HTML][HTML] PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells
S Phadngam, A Castiglioni, A Ferraresi, F Morani… - Oncotarget, 2016 - ncbi.nlm.nih.gov
GLUT1 is the facilitative transporter playing the major role in the internalization of glucose.
Basally, GLUT1 resides on vesicles located in a para-golgian area, and is translocated onto …
Basally, GLUT1 resides on vesicles located in a para-golgian area, and is translocated onto …