Direct cell reprogramming: approaches, mechanisms and progress
The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …
[HTML][HTML] Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning
DJ Drucker - Cell metabolism, 2021 - cell.com
The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people
hospitalized with severe COVID-19 illness has engendered considerable interest in the …
hospitalized with severe COVID-19 illness has engendered considerable interest in the …
[HTML][HTML] Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes
Hormone-secreting cells within pancreatic islets of Langerhans play important roles in
metabolic homeostasis and disease. However, their transcriptional characterization is still …
metabolic homeostasis and disease. However, their transcriptional characterization is still …
SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature
Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme
type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the …
type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the …
[HTML][HTML] RNA sequencing of single human islet cells reveals type 2 diabetes genes
Y **n, J Kim, H Okamoto, M Ni, Y Wei, C Adler… - Cell metabolism, 2016 - cell.com
Pancreatic islet cells are critical for maintaining normal blood glucose levels, and their
malfunction underlies diabetes development and progression. We used single-cell RNA …
malfunction underlies diabetes development and progression. We used single-cell RNA …
β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment
PA Halban, KS Polonsky, DW Bowden… - The Journal of …, 2014 - academic.oup.com
OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …
and suggests areas for future research on the underlying mechanisms that may lead to …
Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes
Blood glucose levels are tightly controlled by the coordinated action of at least four cell types
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …
Single-cell transcriptomics of the human endocrine pancreas
Human pancreatic islets consist of multiple endocrine cell types. To facilitate the detection of
rare cellular states and uncover population heterogeneity, we performed single-cell RNA …
rare cellular states and uncover population heterogeneity, we performed single-cell RNA …
Fox transcription factors: from development to disease
Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …
from yeast to humans. They regulate diverse biological processes both during development …
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
Genetic variation can modulate gene expression, and thereby phenotypic variation and
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …