Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …

Genetic and epigenetic mechanisms regulate the transition from the totipotent zygote to
pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts. These …

METTL3 catalyzes the formation of N 6-methyl-adenosine (m 6 A) which has important roles
in regulating various biological processes. However, the in vivo function of Mettl3 remains …

Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA
replication, transcription, repair, and recombination. The extensive interactions between the …

H1 and related linker histones are important both for maintenance of higher-order chromatin
structure and for the regulation of gene expression. The biology of the linker histones is …

The mechanism by which newly synthesized histones are imported into the nucleus and
deposited onto replicating chromatin alongside segregating nucleosomal counterparts is …

BACKGROUND The development competence of human oocytes declines with increasing
age. The objective of this study was to investigate the effect of age on gene expression …

Proper genome packaging requires coordination of both DNA and histone metabolism.
While histone gene transcription and RNA processing adequately provide for scheduled …

Our genetic information is tightly packaged into a rather ingenious nucleoprotein complex
called chromatin in a manner that enables it to be rapidly accessed during genomic …

The molecular chaperone Hsp90 has been found to be essential for viability in all tested
eukaryotes, from the budding yeast to Drosophila. In mammals, two genes encode the two …