Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …

Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that
nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of …

Active inflammation generally promotes immune activation. However, in the tumor
microenvironment (TME), active inflammation occurs in parallel with immunosuppression …

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …

With the introduction of multiple new agents, the role of immunotherapy is rapidly expanding
across all malignancies. Bladder cancer is known to be immunogenic and is responsive to …

The involvement of the prostaglandin E2 (PGE2) system in cancer progression has long
been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with …

Prostaglandin (PG) E 2 exerts its actions by acting on a group of G-protein-coupled
receptors (GPCRs). There are four GPCRs responding to PGE 2 designated subtypes EP1 …

Prostaglandins are lipid-derived autacoids that modulate many physiological systems
including the CNS, cardiovascular, gastrointestinal, genitourinary, endocrine, respiratory …

It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

Chemoprevention has been considered as a possible approach for cancer prevention. A
significant effort has been made in the development of novel drugs for both cancer …