Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

The known genetic architecture of blood pressure now comprises> 30 genes, with rare
variants resulting in monogenic forms of hypertension or hypotension and> 1,477 common …

Mediation analysis seeks to explain the pathway (s) through which an exposure affects an
outcome. Traditional, non-instrumental variable methods for mediation analysis experience …

The goal of much observational research is to identify risk factors that have a causal effect
on health and social outcomes. However, observational data are subject to biases from …

Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …

Intelligence test scores and educational duration are positively correlated. This correlation
could be interpreted in two ways: Students with greater propensity for intelligence go on to …

Machine learning techniques are increasingly gaining attention due to their widespread use
in various disciplines across academia and industry. Despite their tremendous success …

Objectives To investigate the role of body mass index (BMI), systolic blood pressure, and
smoking behaviour in explaining the effect of education on the risk of cardiovascular disease …

Higher educational attainment is observationally associated with lower risk of Alzheimer's
disease. However, the biological mechanisms underpinning this association remain unclear …

This article extends the existing literature on the health impacts of technological innovations
by investigating both the direct effects of technological innovations on health outcomes and …