Cellular regulation of RGS proteins: modulators and integrators of G protein signaling
Regulators of G protein signaling (RGS) and RGS-like proteins are a family (> 30 members)
of highly diverse, multifunctional signaling proteins that bind directly to activated Gα …
of highly diverse, multifunctional signaling proteins that bind directly to activated Gα …
Regulator of G protein signaling proteins: novel multifunctional drug targets
ABSTARCT G protein-coupled receptors (GPCRs) play a major role in signal transduction
and are targets of many therapeutic drugs. The regulator of G protein signaling (RGS) …
and are targets of many therapeutic drugs. The regulator of G protein signaling (RGS) …
Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer
D Huang, X Chen, X Zeng, L Lao, J Li, Y **ng, Y Lu… - Nature …, 2021 - nature.com
Reduced infiltration of anti-tumor lymphocytes remains a major cause of tumor immune
evasion and is correlated with poor cancer survival. Here, we found that upregulation of …
evasion and is correlated with poor cancer survival. Here, we found that upregulation of …
Intrinsic disorder and protein function
The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
Rgs1 is a regulator of effector gene expression during plant infection by the rice blast fungus Magnaporthe oryzae
To cause rice blast disease, the filamentous fungus Magnaporthe oryzae secretes a battery
of effector proteins into host plant tissue to facilitate infection. Effector-encoding genes are …
of effector proteins into host plant tissue to facilitate infection. Effector-encoding genes are …
Subcellular localization of β-arrestins is determined by their intact N domain and the nuclear export signal at the C terminus
β-Arrestin1 and β-arrestin2 play a key role in the regulation of G protein-coupled receptor-
mediated signaling, whereas the subcellular distribution of β-arrestin1 and β-arrestin2 has …
mediated signaling, whereas the subcellular distribution of β-arrestin1 and β-arrestin2 has …
Can transcription factors function as cell–cell signalling molecules?
Recent data support the view that transcription factors—in particular, homeoproteins—can
be transferred from cell to cell and have direct non-cell-autonomous (and therefore …
be transferred from cell to cell and have direct non-cell-autonomous (and therefore …
Endomembrane-based signaling by GPCRs and G-proteins
G-protein-coupled receptors (GPCRs) and G-proteins have a range of roles in many
physiological and pathological processes and are among the most studied signaling …
physiological and pathological processes and are among the most studied signaling …
RGS5–TGFβ–Smad2/3 axis switches pro-to anti-apoptotic signaling in tumor-residing pericytes, assisting tumor growth
Abstract Regulator-of-G-protein-signaling-5 (RGS5), a pro-apoptotic/anti-proliferative
protein, is a signature molecule of tumor-associated pericytes, highly expressed in several …
protein, is a signature molecule of tumor-associated pericytes, highly expressed in several …
Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons
KL O'Malley, YJI Jong, Y Gonchar, A Burkhalter… - Journal of Biological …, 2003 - jbc.org
Nuclear Ca 2+ plays a critical role in many cellular functions although its mode (s) of
regulation is unclear. This study shows that the metabotropic glutamate receptor, mGlu5 …
regulation is unclear. This study shows that the metabotropic glutamate receptor, mGlu5 …