Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the
uncontrolled proliferation of immature lymphoid cells. Over past decades, significant …

Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …

The last decade has witnessed great advances in our understanding of the genetic and
biological basis of childhood acute lymphoblastic leukemia (ALL), the development of …

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …

Systemic combination chemotherapy and intrathecal chemotherapy markedly increased the
survival rate of children with ALL. In the past two decades, the use of minimal (measurable) …

Advances in genomic research and risk-directed therapy have led to improvements in the
long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic …

Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor
IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are …

As individuals with germ line predisposition to hematologic malignancies are diagnosed
with increasing frequency, the need for clinical surveillance has become apparent …

Purpose Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly
penetrant cancer predisposition condition. Recent reports of germline TP53 variants in …