Particles with ligand–receptor contacts bind and unbind fluctuating “legs” to surfaces, whose
fluctuations cause the particle to diffuse. Quantifying the diffusion of such “nanoscale …

Delays and stochasticity have both served as crucially valuable ingredients in mathematical
descriptions of control, physical and biological systems. In this work, we investigate how …

Transient bonds between fast linkers and slower particles are widespread in physical and
biological systems. Despite their diverse structure and function, a commonality is that the …

The self-organization of cells relies on the profound complexity of protein-protein
interactions. Challenges in directly observing these events have hindered progress toward …

Thermodynamic uncertainty relations have emerged as universal bounds on current
fluctuations in non-equilibrium systems. Here we derive a new bound for a particular class of …

Ball-rolling dung beetles show a remarkable ability to maintain a straight path while rolling
dung balls away from a dung pile. Rolling in a straight line is beneficial, as it enables beetles …

Even though most axonal cargos are synthesized in the soma, the concentration of many of
these cargos is larger at the presynaptic terminal than in the soma. This requires transport of …

We propose a general mathematical and computational approach to study cellular transport
driven by a group of kinesin motors. It is a framework for multi-scale modeling that integrates …

In many biological systems, the movement of individual agents is characterized having
multiple qualitatively distinct behaviors that arise from a variety of biophysical states. For …

Analytical formulas for effective drift, diffusivity, run times, and run lengths are derived for an
intracellular transport system consisting of a cargo attached to two cooperative but not …