Diabetes has been a worldwide healthcare problem for many years. Current methods of
treating diabetes are still largely directed at symptoms, aiming to control the manifestations …

Protein methyltransferases have been shown to methylate histone and non-histone proteins,
leading to regulation of several biological processes that control cell homeostasis. Over the …

The aberrant expression of methyltransferase Set7/9 plays a role in various diseases.
However, the contribution of Set7/9 in ischemic stroke remains unclear. Here, we show …

Epigenetic modifications are chemical modifications that affect gene expression without
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …

Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia
which is caused by insufficient insulin secretion or insulin resistance. Interaction of genetic …

Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence
play an important role in the regulation of the cell's fate. ROS can cause irreversible damage …

The incidence of diabetes is increasing worldwide. Diabetes is quickly becoming one of the
leading causes of death. Diabetes is a genetic disease; however, the environment plays …

Epigenetic modifications are chemical modifications that affect gene expression without
altering DNA sequences. In particular, epigenetic chemical modifications can occur on …

Diabetes mellitus arises from insufficient insulin secretion from pancreatic islet β‐cells. In
type 2 diabetes (T2D), β‐cell dysfunction is associated with inactivation and/or loss of …

The pancreatic and duodenal homeobox 1 (PDX1) is a central regulator of glucose-
dependent transcription of insulin in pancreatic β cells. PDX1 transcription factor activity is …