The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …

The concept of multi-action octahedral platinum (IV) complexes is based on the rational
derivatization of anticancer square-planar platinum (II) compounds (eg, cisplatin or …

The conversion of cisplatin Pt (II) into a Pt (IV) complex is a strategy that can be used to
overcome cisplatin resistance and side effects, and this involves the functionalization of the …

Despite the wide clinical use of platinum drugs in cancer treatment, their severe side effects
and lack of tumor selectivity seriously limit their further clinical application. To address the …

Research on platinum-based anticancer drugs continuously strives to develop new non-
classical platinum complexes. Pt (IV) prodrugs are the most promising, and their activation …

Metal-based inhibitors of histone deacetylases (HDAC), DNA topoisomerases (Topos) and
Epidermal Growth Factor Receptor (EGFR) have demonstrated their cytotoxic potential …

Tumor microenvironment (TME) is known to play a critical role in cancer progression and
contributes to treatment failure or success. Herein, a versatile nanoplatform [HAFOE-Ce6/Pt …

The selectivity vs. cancer cells has always been a major challenge for chemotherapeutic
agents and in particular for cisplatin, one of the most important anticancer drugs for the …

Four acylhydrazone based complexes [TbL (CH 3 OH)(H 2 O)(NO 3) 2]· 0.32 H 2 O (1),[ML
(NO 3)] n M= Pb for (2), M= Zn for (3) and [Ni (HL)(H 2 L)]·(NO 3) 3 (4)(HL= N'-(pyridin-2 …

Triple-negative breast cancer (TNBC) shares the molecular features facilitating epithelial-to-
mesenchymal transition (EMT), which contributed to tumor invasion and metastasis. A …