Immunological memory to SARS‐CoV‐2 infection and COVID‐19 vaccines
Immunological memory is the basis of protective immunity provided by vaccines and
previous infections. Immunological memory can develop from multiple branches of the …
previous infections. Immunological memory can develop from multiple branches of the …
T follicular helper cell biology: a decade of discovery and diseases
S Crotty - Immunity, 2019 - cell.com
Hel** B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …
Long-primed germinal centres with enduring affinity maturation and clonal migration
Germinal centres are the engines of antibody evolution. Here, using human
immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed …
immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed …
Human germinal centres engage memory and naive B cells after influenza vaccination
Influenza viruses remain a major public health threat. Seasonal influenza vaccination in
humans primarily stimulates pre-existing memory B cells, which differentiate into a transient …
humans primarily stimulates pre-existing memory B cells, which differentiate into a transient …
Remembrance of things past: long-term B cell memory after infection and vaccination
AKE Palm, C Henry - Frontiers in immunology, 2019 - frontiersin.org
The success of vaccines is dependent on the generation and maintenance of immunological
memory. The immune system can remember previously encountered pathogens, and …
memory. The immune system can remember previously encountered pathogens, and …
[HTML][HTML] Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance
KM Cirelli, DG Carnathan, B Nogal, JT Martin… - Cell, 2019 - cell.com
Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity
Saponins are potent and safe vaccine adjuvants, but their mechanisms of action remain
incompletely understood. Here, we explored the properties of several saponin formulations …
incompletely understood. Here, we explored the properties of several saponin formulations …
Eliciting B cell immunity against infectious diseases using nanovaccines
A Singh - Nature nanotechnology, 2021 - nature.com
Infectious diseases, including the coronavirus disease 2019 (COVID-19) pandemic that has
brought the world to a standstill, are emerging at an unprecedented rate with a substantial …
brought the world to a standstill, are emerging at an unprecedented rate with a substantial …
Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells
The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in
tissues, is key for a broad range of immunological research, including vaccine responses …
tissues, is key for a broad range of immunological research, including vaccine responses …
Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches
The development of stabilized recombinant HIV envelope trimers that mimic the virion
surface molecule has increased enthusiasm for a neutralizing antibody (nAb)-based HIV …
surface molecule has increased enthusiasm for a neutralizing antibody (nAb)-based HIV …