Genomes 5 has been completely revised and updated. It is a thoroughly modern textbook
about genomes and how they are investigated. As with previous Genomes editions …

The splicing of precursors to mRNAs occurs in two steps, both involving single
transesterification reactions (Fig. 1). The first step generates a 2-5 bond at the branch site …

The **st long noncoding RNA orchestrates X chromosome inactivation, a process that
entails chromosome-wide silencing and remodeling of the three-dimensional (3D) structure …

Interleukin 1β-converting enzyme-like proteases (caspases) are crucial components of cell
death pathways. Among the caspases identified, caspase-3 stands out because it is …

Aberrant RNA splicing in keratinocytes drives inflammatory skin disorders. In the present
study, we found that the RNA helicase DDX5 was downregulated in keratinocytes from the …

The nematode Caenorhabditis elegans has two sexes, males and hermaphrodites.
Hermaphrodites initially produce sperm but switch to producing oocytes. This switch …

Aging is a major risk factor for chronic disease in the human population, but there are little
human data on gene expression alterations that accompany the process. We examined …

Ron, the tyrosine kinase receptor for the Macrophage-stimulating protein, is involved in cell
dissociation, motility, and matrix invasion. ΔRon, a constitutively active isoform that confers …

The Ser-Arg-rich (SR) proteins comprise a large family of nuclear phosphoproteins that are
required for constitutive and alternative splicing. A subset of SR proteins shuttles …

ASF/SF2 is a member of a conserved family of splicing factors known as SR proteins. These
proteins, which are necessary for splicing in vitro, contain one or two amino-terminal RNP …