Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Regulatory T (TReg) cells are essential for maintaining peripheral tolerance, preventing
autoimmune diseases and limiting chronic inflammatory diseases. However, they also limit …

CD4+ T regulatory cells (Treg) are central to immune homeostasis, their phenotypic
heterogeneity reflecting the diverse environments and target cells that they regulate. To …

Monocyte-derived macrophages are essential for recovery after spinal cord injury, but their
homing mechanism is poorly understood. Here, we show that although of common origin …

CD4+ T helper cells are a central element of the adaptive immune system. They protect the
organism against a wide range of pathogens and are able to initiate and control many …

Regulatory T (TReg) cells constitute an essential counterbalance to adaptive immune
responses. Failure to maintain appropriate TReg cell numbers or function leads to …

Regulatory T cells (Tregs) are required to establish immune tolerance to commensal
microbes. Tregs accumulate abruptly in the skin during a defined window of postnatal tissue …

Abstract Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells prevent autoimmune disease,
maintain immune homeostasis and modulate immune responses during infection. To …

Interleukin 17–producing T helper cells (T H-17 cells) are important in experimental
autoimmune encephalomyelitis, but their route of entry into the central nervous system …

Regulatory T cells (Treg cells) are required for peripheral tolerance. Evidence indicates that
Treg cells can adopt specialized differentiation programs in the periphery that are controlled …