T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

MM Painter, TS Johnston, KA Lundgreen… - Nature …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated
individuals is increasingly common but rarely results in severe disease, likely due to the …

Immunological memory diversity in the human upper airway

SI Ramirez, F Faraji, LB Hills, PG Lopez, B Goodwin… - Nature, 2024 - nature.com
The upper airway is an important site of infection, but immune memory in the human upper
airway is poorly understood, with implications for COVID-19 and many other human …

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

DM Altmann, CJ Reynolds, G Joy, AD Otter… - Nature …, 2023 - nature.com
Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in
Long Covid is whether there is a contributory role of abnormal immunity during acute …

Heterotypic immunity from prior SARS-CoV-2 infection but not COVID-19 vaccination associates with lower endemic coronavirus incidence

DJ Bean, J Monroe, YM Liang, E Borberg… - Science translational …, 2024 - science.org
Immune responses from prior severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) infection and COVID-19 vaccination mitigate disease severity, but they do not fully prevent …

Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults

H Kared, AS Wolf, A Alirezaylavasani… - Nature …, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant has more than 15 mutations in the receptor
binding domain of the Spike protein enabling increased transmissibility and viral escape …

Nucleocapsid-specific T cell responses associate with control of SARS-CoV-2 in the upper airways before seroconversion

TM Eser, O Baranov, M Huth, MIM Ahmed… - Nature …, 2023 - nature.com
Despite intensive research since the emergence of SARS-CoV-2, it has remained unclear
precisely which components of the early immune response protect against the development …

Epidemiological and clinical characteristics of vaccinated COVID-19 patients: a meta-analysis and systematic review

W Tian, X Ren, M Han, Y Zhang… - International …, 2022 - journals.sagepub.com
Objective: With the global epidemic of coronavirus disease 2019 (COVID-19), vaccination
rates are increasing globally. This study evaluated the relevant clinical manifestations of …

SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors

C Choy, J Chen, J Li, DT Gallagher, J Lu, D Wu… - Nature …, 2023 - nature.com
The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+
T cells play a vital role. Nonetheless, the characterization of the specificity and TCR …

[HTML][HTML] Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic

ED Yu, TM Narowski, E Wang, E Garrigan, J Mateus… - Cell host & …, 2022 - cell.com
The immune memory to common cold coronaviruses (CCCs) influences SARS-CoV-2
infection outcome, and understanding its effect is crucial for pan-coronavirus vaccine …