LPA receptor signaling: pharmacology, physiology, and pathophysiology
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
LPA receptors: subtypes and biological actions
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …
signaling molecule by binding to and activating at least five known G protein–coupled …
Lysophospholipid receptor nomenclature review: IUPHAR Review 8
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …
that act as extracellular signals. The signalling properties are mediated by 7 …
Lysophosphatidic acid (LPA) and its receptors
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-
coupled receptors have demonstrated roles in many biological functions in the nervous …
coupled receptors have demonstrated roles in many biological functions in the nervous …
Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus
Neurogenesis persists in certain regions of the adult brain including the subgranular zone of
the hippocampal dentate gyrus wherein its regulation is essential, particularly in relation to …
the hippocampal dentate gyrus wherein its regulation is essential, particularly in relation to …
[HTML][HTML] Lysophosphatidic acid receptors: biochemical and clinical implications in different diseases
H **ang, Y Lu, M Shao, T Wu - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Abstract Lysophosphatidic acid (LPA, 1-acyl-2-hemolytic-sn-glycerol-3-phosphate) extracted
from membrane phospholipid is a kind of simple bioactive glycophospholipid, which has …
from membrane phospholipid is a kind of simple bioactive glycophospholipid, which has …
LPA4/p2y9/GPR23 mediates rho-dependent morphological changes in a rat neuronal cell line
K Yanagida, S Ishii, F Hamano, K Noguchi… - Journal of Biological …, 2007 - ASBMB
Lysophosphatidic acid (LPA) is a potent lipid mediator that evokes a variety of biological
responses in many cell types via its specific G protein-coupled receptors. In particular, LPA …
responses in many cell types via its specific G protein-coupled receptors. In particular, LPA …
Autotaxin–lysophosphatidic acid signaling in alzheimer's disease
The brain contains various forms of lipids that are important for maintaining its structural
integrity and regulating various signaling cascades. Autotaxin (ATX) is an ecto-nucleotide …
integrity and regulating various signaling cascades. Autotaxin (ATX) is an ecto-nucleotide …
Stem cell regulation by lysophospholipids
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) regulate a diverse range
of mammalian cell processes, largely through engaging multiple G protein-coupled …
of mammalian cell processes, largely through engaging multiple G protein-coupled …
Aggravation of Chronic Stress Effects on Hippocampal Neurogenesis and Spatial Memory in LPA1 Receptor Knockout Mice
Background The lysophosphatidic acid LPA1 receptor regulates plasticity and neurogenesis
in the adult hippocampus. Here, we studied whether absence of the LPA1 receptor …
in the adult hippocampus. Here, we studied whether absence of the LPA1 receptor …