LPA receptor signaling: pharmacology, physiology, and pathophysiology

YC Yung, NC Stoddard, J Chun - Journal of lipid research, 2014 - ASBMB
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

LPA receptors: subtypes and biological actions

JW Choi, DR Herr, K Noguchi, YC Yung… - Annual review of …, 2010 - annualreviews.org
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

Y Kihara, M Maceyka, S Spiegel… - British journal of …, 2014 - Wiley Online Library
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …

Lysophosphatidic acid (LPA) and its receptors

K Noguchi, D Herr, T Mutoh, J Chun - Current opinion in pharmacology, 2009 - Elsevier
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-
coupled receptors have demonstrated roles in many biological functions in the nervous …

Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus

E Matas-Rico, B García-Diaz, P Llebrez-Zayas… - Molecular and Cellular …, 2008 - Elsevier
Neurogenesis persists in certain regions of the adult brain including the subgranular zone of
the hippocampal dentate gyrus wherein its regulation is essential, particularly in relation to …

[HTML][HTML] Lysophosphatidic acid receptors: biochemical and clinical implications in different diseases

H **ang, Y Lu, M Shao, T Wu - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Abstract Lysophosphatidic acid (LPA, 1-acyl-2-hemolytic-sn-glycerol-3-phosphate) extracted
from membrane phospholipid is a kind of simple bioactive glycophospholipid, which has …

LPA4/p2y9/GPR23 mediates rho-dependent morphological changes in a rat neuronal cell line

K Yanagida, S Ishii, F Hamano, K Noguchi… - Journal of Biological …, 2007 - ASBMB
Lysophosphatidic acid (LPA) is a potent lipid mediator that evokes a variety of biological
responses in many cell types via its specific G protein-coupled receptors. In particular, LPA …

Autotaxin–lysophosphatidic acid signaling in alzheimer's disease

S Ramesh, M Govindarajulu, V Suppiramaniam… - International journal of …, 2018 - mdpi.com
The brain contains various forms of lipids that are important for maintaining its structural
integrity and regulating various signaling cascades. Autotaxin (ATX) is an ecto-nucleotide …

Stem cell regulation by lysophospholipids

A Pébay, CS Bonder, SM Pitson - Prostaglandins & other lipid mediators, 2007 - Elsevier
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) regulate a diverse range
of mammalian cell processes, largely through engaging multiple G protein-coupled …

Aggravation of Chronic Stress Effects on Hippocampal Neurogenesis and Spatial Memory in LPA1 Receptor Knockout Mice

E Castilla-Ortega, C Hoyo-Becerra, C Pedraza, J Chun… - PloS one, 2011 - journals.plos.org
Background The lysophosphatidic acid LPA1 receptor regulates plasticity and neurogenesis
in the adult hippocampus. Here, we studied whether absence of the LPA1 receptor …