Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are
degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

INTRODUCTION Mitochondria are essential organelles whose form and function are
inextricably linked. Balanced fusion and fission events shape mitochondria to meet …

The process of mitochondrial dynamics is emerging as a core player in cardiovascular
homeostasis. This process refers to the co‐ordinated cycles of biogenesis, fusion, fission …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

Mitochondria are primarily responsible for providing the contracting cardiac myocyte with a
continuous supply of ATP. However, mitochondria can rapidly change into death-promoting …

The mitochondria are double-membrane organelles integral for energy metabolism.
Mitochondrial dynamics is regulated by inner and outer mitochondrial membrane (IMM and …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Most, if not all mitochondrial functions, including adenosine-5′-triphosphate (ATP)
production and regulation of apoptosis and Ca 2+ homeostasis, are inextricably linked to …

Cardiovascular diseases remain the leading cause of death worldwide in the last decade,
accompanied by immense health and economic burdens. Heart failure (HF), as the terminal …