The IL-17 family in diseases: from bench to bedside

L Huangfu, R Li, Y Huang, S Wang - Signal transduction and targeted …, 2023 - nature.com
Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

Inflammation and cancer: triggers, mechanisms, and consequences

FR Greten, SI Grivennikov - Immunity, 2019 - cell.com
Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …

A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers

M Fidelle, C Rauber, C Alves Costa Silva, AL Tian… - Science, 2023 - science.org
Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1)
blockade in cancer patients, but the mechanisms underlying their immunosuppressive …

Cytokine‐and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy

AA Bhat, S Nisar, M Singh, B Ashraf… - Cancer …, 2022 - Wiley Online Library
Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …

Regulatory T cells in the face of the intestinal microbiota

D Ramanan, A Pratama, Y Zhu, O Venezia… - Nature Reviews …, 2023 - nature.com
Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with
microorganisms and food antigens at intestinal borders. Startling new information has …

[HTML][HTML] Inflammation-induced tumorigenesis and metastasis

S Hibino, T Kawazoe, H Kasahara, S Itoh… - International journal of …, 2021 - mdpi.com
Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

Roles of Porphyromonas gingivalis and its virulence factors in periodontitis

W Xu, W Zhou, H Wang, S Liang - Advances in protein chemistry and …, 2020 - Elsevier
Periodontitis is an infection-driven inflammatory disease, which is characterized by gingival
inflammation and bone loss. Periodontitis is associated with various systemic diseases …

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

DJ Baker, BG Childs, M Durik, ME Wijers, CJ Sieben… - Nature, 2016 - nature.com
Cellular senescence, a stress-induced irreversible growth arrest often characterized by
expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a …

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

T Saito, H Nishikawa, H Wada, Y Nagano… - Nature medicine, 2016 - nature.com
CD4+ T cells that express the forkhead box P3 (FOXP3) transcription factor function as
regulatory T (Treg) cells and hinder effective immune responses against cancer cells …

Dietary fat, bile acid metabolism and colorectal cancer

S Ocvirk, SJD O'Keefe - Seminars in cancer biology, 2021 - Elsevier
Colorectal cancer (CRC) risk is predominantly driven by environmental factors, in particular
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …