Genetic and biological hallmarks of colorectal cancer
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …
tumors, and these insights have illuminated early detection, risk stratification, prevention …
Phenotypic plasticity and genetic control in colorectal cancer evolution
Genetic and epigenetic variation, together with transcriptional plasticity, contribute to
intratumour heterogeneity. The interplay of these biological processes and their respective …
intratumour heterogeneity. The interplay of these biological processes and their respective …
Genetic alterations of metastatic colorectal cancer
Genome sequencing studies have characterized the genetic alterations of different tumor
types, highlighting the diversity of the molecular processes driving tumor development …
types, highlighting the diversity of the molecular processes driving tumor development …
State-dependent evolutionary models reveal modes of solid tumour growth
Spatial properties of tumour growth have profound implications for cancer progression,
therapeutic resistance and metastasis. Yet, how spatial position governs tumour cell division …
therapeutic resistance and metastasis. Yet, how spatial position governs tumour cell division …
Tumor phylogeography reveals block-shaped spatial heterogeneity and the mode of evolution in Hepatocellular Carcinoma
Solid tumors are complex ecosystems with heterogeneous 3D structures, but the spatial intra-
tumor heterogeneity (sITH) at the macroscopic (ie, whole tumor) level is under-explored …
tumor heterogeneity (sITH) at the macroscopic (ie, whole tumor) level is under-explored …
Spatial structure governs the mode of tumour evolution
Characterizing the mode—the way, manner or pattern—of evolution in tumours is important
for clinical forecasting and optimizing cancer treatment. Sequencing studies have inferred …
for clinical forecasting and optimizing cancer treatment. Sequencing studies have inferred …
Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors
Colorectal cancer exhibits dynamic cellular and genetic heterogeneity during progression
from precursor lesions toward malignancy. Analysis of spatial multi-omic data from 31 …
from precursor lesions toward malignancy. Analysis of spatial multi-omic data from 31 …
Impact of TP53 mutations in triple negative breast cancer
ZI Mitri, N Abuhadra, SM Goodyear, EA Hobbs… - NPJ Precision …, 2022 - nature.com
Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes
provides an opportunity to enhance clinical management. We applied an Evolutionary …
provides an opportunity to enhance clinical management. We applied an Evolutionary …
Zebrafish xenograft as a tool for the study of colorectal cancer: a review
Colorectal cancer (CRC) is the second leading cause of cancer-related death, mostly due to
metastatic disease and the fact that many patients already show signs of metastasis at the …
metastatic disease and the fact that many patients already show signs of metastasis at the …
Molecular insights of metastasis and cancer progression derived using 3D cancer spheroid co-culture in vitro platform
The multistep metastasis process is carried out by the combinatorial effect of the stromal
cells and the cancerous cells and plays vital role in the cancer progression. The …
cells and the cancerous cells and plays vital role in the cancer progression. The …