Thanks to its safety and accessibility, magnetic resonance imaging (MRI) is extensively used
in clinical routine and research field, largely contributing to our understanding of the …

Currently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors
represents the main available approach to treat cognitive and behavioural symptoms of the …

The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …

There is considerable debate whether Alzheimer's disease (AD) originates in basal
forebrain or entorhinal cortex. Here we examined whether longitudinal decreases in basal …

As indicated by the profound cognitive impairments caused by cholinergic receptor
antagonists, cholinergic neurotransmission has a vital role in cognitive function, specifically …

Theories of instrumental learning are centred on understanding how success and failure are
used to improve future decisions. These theories highlight a central role for reward …

Increases in attentional effort are defined as the motivated activation of attentional systems
in response to detrimental challenges on attentional performance, such as the presentation …

Acetylcholine (ACh) is a neuromodulatory transmitter implicated in perception and learning
under uncertainty. This study combined computational simulations and pharmaco …

Historically, ACh has been implicated in learning and short-term memory functions.
However, more recent studies have provided support for a role of cortical ACh in attentional …