Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …

Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Hydrogen isotopes are unique tools for identifying and understanding biological and
chemical processes. Hydrogen isotope labelling allows for the traceless and direct …

Owing to their morphological complexity and dense network connections, neurons modify
their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue …

Abstract Proteolysis-Targeting Chimeras (PROTACs) are heterobifunctional small-molecules
that can promote the rapid and selective proteasome-mediated degradation of intracellular …

Rapid protein degradation enables cells to quickly modulate protein abundance.
Dysregulation of short-lived proteins plays essential roles in disease pathogenesis. A …

Gene expression is a multistep process that involves the transcription, translation and
turnover of messenger RNAs and proteins. Although it is one of the most fundamental …

The clinical and commercial success of covalent drugs has prompted a renewed and more
deliberate pursuit of covalent and irreversible mechanisms within drug discovery. A covalent …

The ubiquitin system is a major coordinator of cellular physiology through regulation of both
protein degradation and signalling pathways. A key building block of a systems-level …

Do young and old protein molecules have the same probability to be degraded? We
addressed this question using metabolic pulse-chase labeling and quantitative mass …