The α-Gal syndrome and potential mechanisms

P Román-Carrasco, W Hemmer, A Cabezas-Cruz… - Frontiers in …, 2021 - frontiersin.org
The α-Gal syndrome is a complex allergic disease characterized by the development of
specific IgE antibodies against the carbohydrate galactose-α-1, 3-galactose (α-Gal), an …

Current and future strategies for the diagnosis and treatment of the alpha-gal syndrome (AGS)

R Vaz-Rodrigues, L Mazuecos… - Journal of asthma and …, 2022 - Taylor & Francis
The α-Gal syndrome (AGS) is a pathognomonic immunoglobulin E (IgE)-mediated delayed
anaphylaxis in foods containing the oligosaccharide galactose-α-1, 3-galactose (α-Gal) such …

The meat of the matter: understanding and managing alpha-gal syndrome

JD Macdougall, KO Thomas… - ImmunoTargets and …, 2022 - Taylor & Francis
Alpha-gal syndrome is an unconventional food allergy, characterized by IgE-mediated
hypersensitivity responses to the glycan galactose-alpha-1, 3-galactose (alpha-gal) and not …

Characterization of tick salivary gland and saliva alphagalactome reveals candidate alpha-gal syndrome disease biomarkers

M Villar, I Pacheco, L Mateos-Hernández… - Expert Review of …, 2021 - Taylor & Francis
Background Ticks are obligate hematophagous arthropods that synthesize the glycan Galα1-
3Galβ1-(3) 4GlcNAc-R (α-Gal) associated with the alpha-gal syndrome (AGS) or allergy to …

Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model

SR Sharma, SK Choudhary, J Vorobiov… - Frontiers in …, 2024 - frontiersin.org
Introduction Alpha-Gal Syndrome (AGS) is a delayed allergic reaction due to specific IgE
antibodies targeting galactose-α-1, 3-galactose (α-gal), a carbohydrate found in red meat …

[HTML][HTML] Tick bite as a risk factor for alpha-gal–specific immunoglobulin E antibodies and development of alpha-gal syndrome

GJ Kersh, J Salzer, ES Jones, AM Binder… - Annals of Allergy …, 2023 - Elsevier
Background The disaccharide galactose-α-1, 3-galactose (alpha-gal) is expressed in
mammals other than humans, apes, and old-world monkeys. In humans, elevated …

Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome

D Apostolovic, J Grundström… - The Journal of …, 2023 - Am Soc Clin Investig
Tick bites have been shown to transmit a novel form of severe food allergy, the galactose-α-
1, 3-galactose (α-Gal) syndrome (AGS). Cellular responses to α-Gal in patients with AGS …

Tick bites, IgE to galactose‐alpha‐1, 3‐galactose and urticarial or anaphylactic reactions to mammalian meat: The alpha‐gal syndrome

JM Wilson, L Erickson, M Levin, SM Ailsworth… - Allergy, 2024 - Wiley Online Library
The recent recognition of a syndrome of tick‐acquired mammalian meat allergy has
transformed the previously held view that mammalian meat is an uncommon allergen. The …

Alpha-Gal Syndrome: Involvement of Amblyomma americanum α-D-Galactosidase and β-1,4 Galactosyltransferase Enzymes in α-Gal Metabolism

SR Sharma, G Crispell, A Mohamed, C Cox… - Frontiers in Cellular …, 2021 - frontiersin.org
Alpha-Gal Syndrome (AGS) is an IgE-mediated delayed-type hypersensitivity reaction to the
oligosaccharide galactose-α-1, 3-galactose (α-gal) injected into humans from the lone-star …

Where's the beef? Understanding allergic responses to red meat in alpha-gal syndrome

AS Carson, A Gardner, OI Iweala - The Journal of Immunology, 2022 - journals.aai.org
Alpha-gal syndrome (AGS) describes a collection of symptoms associated with IgE-
mediated hypersensitivity responses to the glycan galactose-alpha-1, 3-galactose (alpha …