The blood-brain barrier (BBB) has been a great hurdle for brain drug delivery. The BBB in
healthy brain is a diffusion barrier essential for protecting normal brain function by impeding …

Over the past decade, we have made considerable progress in establishing diffuse intrinsic
pontine glioma (DIPG) as a disease entity and develo** preclinical tools to interrogate …

Glioblastoma multiforme (GBM) is one of the most aggressive cancers, where the
aggressiveness of tumor has been associated to its high vascularization rate. Bevacizumab …

Background The aim of this study was to investigate the potential of combined textural
feature analysis of contrast-enhanced MRI (CE-MRI) and static O-(2-[18 F] fluoroethyl)-L …

Gliomas are the most aggressive and lethal tumors of the central nervous system, for which
few therapeutic options exist. Surgical resection is the primary treatment for most gliomas; …

Background Diagnostic accuracy in previous studies of O-(2-[18F]-fluoroethyl)-L-tyrosine
(18F-FET) PET in patients with suspected recurrent glioma may be influenced by prolonged …

Background The goal of this prospective study was to compare the value of both
conventional MRI and O-(2-18 F-fluoroethyl)-L-tyrosine (FET) PET for response evaluation in …

Therapeutic brain irradiation with ionizing radiation exerts multiple side effects including
barrier leakage that disturbs glial‐neuronal functioning and may affect cognition. Astrocytes …

Background MRI-based differential diagnosis of glioma recurrence (GR) and treatment-
induced changes (TICs) remain elusive in up to 30% of treated glioma patients. We aimed to …

Imaging plays a critical role in the management of the highly complex and widely diverse
central nervous system (CNS) malignancies in providing an accurate diagnosis, treatment …