Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

Non-union of bone following fracture is an orthopaedic condition with a high morbidity and
clinical burden. Despite its estimated global prevalence of nine million annually, the limit of …

Disuse osteoporosis is characterized by decreased bone mass caused by abnormal
mechanical stimulation of bone. Piezo1 is a major mechanosensitive ion channel in bone …

Treatment of bone defects remains a challenge in the clinic. Artificial bone grafts are the
most promising alternative to autologous bone grafting. However, one of the limiting factors …

Skeletal homeostasis requires the continued replenishment of the bone forming osteoblast
from a mesenchymal stem cell (MSC) population, a process that has been shown to be …

In the past decade, extracellular vesicles (EVs) have emerged as key regulators of bone
development, homeostasis and repair. EV-based therapies have the potential to …

Bone formation or regeneration requires the recruitment, proliferation, and osteogenic
differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is …

Bone marrow mesenchymal stem cells (BMSCs) refer to a heterogeneous population of cells
with the capacity for self-renewal. BMSCs have multi-directional differentiation potential and …

In bone tissue engineering research, bioreactors designed for replicating the main features
of the complex native environment represent powerful investigation tools. Moreover, when …