Big data analytics in healthcare

A Belle, R Thiagarajan… - BioMed research …, 2015 - Wiley Online Library
The rapidly expanding field of big data analytics has started to play a pivotal role in the
evolution of healthcare practices and research. It has provided tools to accumulate, manage …

Improving nitrogen use efficiency in crops for sustainable agriculture

B Hirel, T Tétu, PJ Lea, F Dubois - Sustainability, 2011 - mdpi.com
In this review, we present the recent developments and future prospects of improving
nitrogen use efficiency (NUE) in crops using various complementary approaches. These …

Topological analysis and interactive visualization of biological networks and protein structures

NT Doncheva, Y Assenov, FS Domingues… - Nature protocols, 2012 - nature.com
Computational analysis and interactive visualization of biological networks and protein
structures are common tasks for gaining insight into biological processes. This protocol …

Systematic comparison of C3 and C4 plants based on metabolic network analysis

C Wang, L Guo, Y Li, Z Wang - BMC systems biology, 2012 - Springer
Background The C4 photosynthetic cycle supercharges photosynthesis by concentrating CO
2 around ribulose-1, 5-bisphosphate carboxylase and significantly reduces the oxygenation …

Path2Models: large-scale generation of computational models from biochemical pathway maps

F Büchel, N Rodriguez, N Swainston, C Wrzodek… - BMC systems …, 2013 - Springer
Background Systems biology projects and omics technologies have led to a growing
number of biochemical pathway models and reconstructions. However, the majority of these …

Multiscale metabolic modeling: dynamic flux balance analysis on a whole-plant scale

E Grafahrend-Belau, A Junker, A Eschenröder… - Plant …, 2013 - academic.oup.com
Plant metabolism is characterized by a unique complexity on the cellular, tissue, and organ
levels. On a whole-plant scale, changing source and sink relations accompanying plant …

The metabolic blueprint of Phaeodactylum tricornutum reveals a eukaryotic Entner–Doudoroff glycolytic pathway

M Fabris, M Matthijs, S Rombauts… - The Plant …, 2012 - Wiley Online Library
Diatoms are one of the most successful groups of unicellular eukaryotic algae. Successive
endosymbiotic events contributed to their flexible metabolism, making them competitive in …

Systems physiology in dairy cattle: nutritional genomics and beyond

JJ Loor, M Bionaz, JK Drackley - Annu. Rev. Anim. Biosci., 2013 - annualreviews.org
Microarray development changed the way biologists approach the holistic study of cells and
tissues. In dairy cattle biosciences, the application of omics technology, from spotted …

MetRxn: a knowledgebase of metabolites and reactions spanning metabolic models and databases

A Kumar, PF Suthers, CD Maranas - BMC bioinformatics, 2012 - Springer
Background Increasingly, metabolite and reaction information is organized in the form of
genome-scale metabolic reconstructions that describe the reaction stoichiometry …

Flux-balance modeling of plant metabolism

LJ Sweetlove, RG Ratcliffe - Frontiers in plant science, 2011 - frontiersin.org
Flux-balance modeling of plant metabolic networks provides an important complement to
13C-based metabolic flux analysis. Flux-balance modeling is a constraints-based approach …