Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape
tissues, influence social interactions, and protect against pathogens and other …

Protein self-assembly is one of the formation mechanisms of biomolecular condensates.
However, most phase-separating systems (PS) demand multiple partners in biological …

INTRODUCTION Most newly synthesized proteins associate into macromolecular
complexes to become functional. Complex formation requires that subunits find each other …

Autophagy is a degradative pathway required to maintain homeostasis. Neuronal
autophagosomes form constitutively at the axon terminal and mature via lysosomal fusion …

DNA double-strand breaks (DSBs) threaten genome stability throughout life and are linked
to tumorigenesis in humans. To initiate DSB repair by end joining or homologous …

Obtaining the high-resolution structures of proteins and their complexes is a crucial aspect of
understanding the mechanisms of life. Experimental structure determination methods are …

Motivation Protein–protein interactions are central to all biological processes. One frequently
observed mode of such interactions is the α-helical coiled coil (CC). Thus, an ability to …

In many organs, small openings across capillary endothelial cells (ECs) allow the diffusion
of low–molecular weight compounds and small proteins between the blood and tissue …

The Toxoplasma inner membrane complex (IMC) is a unique organelle that plays critical
roles in parasite motility, invasion, egress, and replication. The IMC is delineated into the …