Recent efforts to construct reference maps of cellular phenotypes have expanded the
volume and diversity of single-cell omics data, providing an unprecedented resource for …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Hundreds of millions of single cells have been analyzed using high-throughput
transcriptomic methods. The cumulative knowledge within these datasets provides an …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and
limited treatment options. Efforts to identify effective treatments are thwarted by limited …

Age is a major risk factor for cancer, but how aging impacts tumor control remains unclear. In
this study, we establish that aging of the immune system, regardless of the age of the stroma …

Joint analysis of single-cell genomics data from diseased tissues and a healthy reference
can reveal altered cell states. We investigate whether integrated collections of data from …

Identifying cellular identities is a key use case in single-cell transcriptomics. While machine
learning has been leveraged to automate cell annotation predictions for some time, there …

Group 1 innate lymphoid cells (ILC1s) are cytotoxic and interferon gamma-producing
lymphocytes lacking antigen-specific receptors, which include ILC1s and natural killer (NK) …

Speciation leads to adaptive changes in organ cellular physiology and creates challenges
for studying rare cell-type functions that diverge between humans and mice. Rare cystic …

In recent years, major advances have been made in the understanding of the cellular and
molecular mechanisms driving pulmonary vascular remodelling in various forms of …