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Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators
Y Yang, GC Lee, E Nakagaki-Silva… - Nucleic Acids …, 2023 - academic.oup.com
Alternative pre-mRNA splicing decisions are regulated by RNA binding proteins (RBPs) that
can activate or repress regulated splice sites. Repressive RBPs typically harness multivalent …
can activate or repress regulated splice sites. Repressive RBPs typically harness multivalent …
Mechanism of an alternative splicing switch mediated by cell-specific and general splicing regulators
Y Yang, GC Lee, E Nakagaki-Silva, Y Huang… - bioRxiv, 2023 - biorxiv.org
Alternative pre-mRNA splicing is regulated by RNA binding proteins (RBPs) that activate or
repress regulated splice sites. Repressive RBPs bind stably to target RNAs via multivalent …
repress regulated splice sites. Repressive RBPs bind stably to target RNAs via multivalent …