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New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation
N Zisapel - British journal of pharmacology, 2018 - Wiley Online Library
In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the
hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light …
hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light …
Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways
SR Pandi-Perumal, I Trakht, V Srinivasan… - Progress in …, 2008 - Elsevier
Melatonin, an endogenous signal of darkness, is an important component of the body's
internal time-kee** system. As such it regulates major physiological processes including …
internal time-kee** system. As such it regulates major physiological processes including …
Melatonin and its analogs in insomnia and depression
DP Cardinali, V Srinivasan, A Brzezinski… - Journal of pineal …, 2012 - Wiley Online Library
Benzodiazepine sedative‐hypnotic drugs are widely used for the treatment of insomnia.
Nevertheless, their adverse effects, such as next‐day hangover, dependence and …
Nevertheless, their adverse effects, such as next‐day hangover, dependence and …
Recent advances in the utilization of tea active ingredients to regulate sleep through neuroendocrine pathway, immune system and intestinal microbiota
Y Wei, J Xu, S Miao, K Wei, L Peng… - Critical Reviews in …, 2023 - Taylor & Francis
Sleep disorders have received widespread attention nowadays, which have been promoted
by the accelerated pace of life, unhealthy diets and lack of exercise in modern society. The …
by the accelerated pace of life, unhealthy diets and lack of exercise in modern society. The …
The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature
RB Costello, CV Lentino, CC Boyd, ML O'Connell… - Nutrition journal, 2014 - Springer
A systematic review was conducted using Samueli Institute's Rapid Evidence Assessment of
the Literature (REAL©) process to determine the evidence base for melatonin as an agent to …
the Literature (REAL©) process to determine the evidence base for melatonin as an agent to …
Prolonged‐release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects
P Lemoine, T Nir, M Laudon… - Journal of sleep …, 2007 - Wiley Online Library
Melatonin, secreted nocturnally by the pineal gland, is an endogenous sleep regulator.
Impaired melatonin production and complaints on poor quality of sleep are common among …
Impaired melatonin production and complaints on poor quality of sleep are common among …
Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes
AG Wade, I Ford, G Crawford… - … medical research and …, 2007 - Taylor & Francis
Objective: Melatonin, the hormone produced nocturnally by the pineal gland, serves as a
circadian time cue and sleep-anticipating signal in humans. With age, melatonin production …
circadian time cue and sleep-anticipating signal in humans. With age, melatonin production …
The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders
JE Jan, RJ Reiter, MB Wasdell… - Journal of pineal …, 2009 - Wiley Online Library
The thalamus has a strong nonphotic influence on sleep, circadian rhythmicity, pineal
melatonin production, and secretion. The opening of the sleep gate for nonrapid eye …
melatonin production, and secretion. The opening of the sleep gate for nonrapid eye …
[HTML][HTML] Therapeutic effects of melatonin receptor agonists on sleep and comorbid disorders
M Laudon, A Frydman-Marom - International journal of molecular …, 2014 - mdpi.com
Several melatonin receptors agonists (ramelteon, prolonged-release melatonin,
agomelatine and tasimelteon) have recently become available for the treatment of insomnia …
agomelatine and tasimelteon) have recently become available for the treatment of insomnia …
Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as …
AG Wade, I Ford, G Crawford, A McConnachie, T Nir… - BMC medicine, 2010 - Springer
Background Melatonin is extensively used in the USA in a non-regulated manner for sleep
disorders. Prolonged release melatonin (PRM) is licensed in Europe and other countries for …
disorders. Prolonged release melatonin (PRM) is licensed in Europe and other countries for …