Nonsynaptic chemical transmission through nicotinic acetylcholine receptors
This review attempts to organize the different aspects of nicotinic transmission in the context
of nonsynaptic interactions. Nicotinic acetylcholine receptors (nAChRs) dominantly operate …
of nonsynaptic interactions. Nicotinic acetylcholine receptors (nAChRs) dominantly operate …
Nicotine reduction revisited: science and future directions
Regulation of nicotine levels in cigarettes and other tobacco products is now possible with
the passage of the Family Smoking Prevention and Tobacco Control Act (FSPTCA) in 2009 …
the passage of the Family Smoking Prevention and Tobacco Control Act (FSPTCA) in 2009 …
Cholinergic modulation of microglial activation by α7 nicotinic receptors
RD Shytle, T Mori, K Townsend… - Journal of …, 2004 - Wiley Online Library
Almost all degenerative diseases of the CNS are associated with chronic inflammation. A
central step in this process is the activation of brain mononuclear phagocyte cells, called …
central step in this process is the activation of brain mononuclear phagocyte cells, called …
Smoking and structural brain deficits: a volumetric MR investigation
J Gallinat, E Meisenzahl, LK Jacobsen… - European Journal of …, 2006 - Wiley Online Library
Growing evidence from animal studies indicates brain‐damaging properties of nicotine
exposure. Investigations in humans found a wide range of functional cerebral effects of …
exposure. Investigations in humans found a wide range of functional cerebral effects of …
A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in …
Purpose: To determine whether the preclinical antitumor and antiangiogenic activity of 2-
methoxyestradiol can be translated to the clinic. Experimental Design: Men with hormone …
methoxyestradiol can be translated to the clinic. Experimental Design: Men with hormone …
Imaging nicotine in rat brain tissue by use of nanospray desorption electrospray ionization mass spectrometry
Imaging mass spectrometry offers simultaneous spatially resolved detection of drugs, drug
metabolites, and endogenous substances in a single experiment. This is important when …
metabolites, and endogenous substances in a single experiment. This is important when …
[HTML][HTML] Adult and periadolescent rats differ in expression of nicotinic cholinergic receptor subtypes and in the response of these subtypes to chronic nicotine exposure
MB Doura, AB Gold, AB Keller, DC Perry - Brain research, 2008 - Elsevier
Adolescence is a time of significant brain development, and exposure to nicotine during this
period is associated with higher subsequent rates of dependence. Chronic nicotine …
period is associated with higher subsequent rates of dependence. Chronic nicotine …
Nicotine inhibits microglial proliferation and is neuroprotective in global ischemia rats
YZ Guan, XD **, LX Guan, HC Yan, P Wang… - Molecular …, 2015 - Springer
Ischemic injury in rodent models reliably leads to the activation of microglia, which might
play a detrimental role in neuronal survival. Our preliminary studies suggest that nicotine …
play a detrimental role in neuronal survival. Our preliminary studies suggest that nicotine …
British American tobacco on facebook: undermining Article 13 of the global World Health Organization framework convention on tobacco control
Background The World Health Organization Framework Convention on Tobacco Control
(WHO FCTC) bans all forms of tobacco advertising, promotion and sponsorship. The …
(WHO FCTC) bans all forms of tobacco advertising, promotion and sponsorship. The …
Nicotine's oxidative and antioxidant properties in CNS
Nicotine has been reported to be therapeutic in some patients with certain
neurodegenerative diseases and to have neuroprotective effects in the central nervous …
neurodegenerative diseases and to have neuroprotective effects in the central nervous …