Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach

E Haghighi, SS Abolmaali, A Dehshahri… - Journal of …, 2024 - Springer
RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for
treating diverse diseases. However, their potential is commonly hindered by vulnerability to …

Modular Design of Lipopeptide‐Based Organ‐Specific Targeting (POST) Lipid Nanoparticles for Highly Efficient RNA Delivery

C Tang, Y Zhang, B Li, X Fan, Z Wang, R Su… - Advanced …, 2025 - Wiley Online Library
Lipid nanoparticles (LNPs) with highly efficient and specific extrahepatic targeting abilities
are promising in gene delivery, and the lipopeptides (LPs) with excellent designability and …

Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen

L Xue, X **ong, G Zhao, W Molina-Arocho… - Journal of the …, 2025 - ACS Publications
Lipid nanoparticles (LNPs) have emerged as pivotal vehicles for messenger RNA (mRNA)
delivery to hepatocytes upon systemic administration and to antigen-presenting cells …

[PDF][PDF] Advancements in genetic circuits as part of intelligent biotherapy for the treatment of bladder cancer: A review

C Liu, J Lu, J Lai, K Jie, T Lin, H Wang, X Chen - 2025 - web-api.polscientific.com
Background: Bladder cancer poses a significant threat to human health. In recent years,
genetic circuit therapy has emerged as a novel alternative for precision tumor treatment …

A Quarter Century of Calcium-Permeable Ion Channel, TRPV4: Perspectives on Expression and Function in Endothelial Cells-Time to Translate

W Liedtke - TRPV4: Perspectives on Expression and Function in …, 2025 - papers.ssrn.com
Calcium-permeable transient receptor potential cation channel subfamily V member 4
(TRPV4) channels, first described in 2000, are activated by osmotic, mechanical, thermal …