The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Carbon nanomaterials: Synthesis, functionalization and sensing applications

G Speranza - Nanomaterials, 2021 - mdpi.com
Recent advances in nanomaterial design and synthesis has resulted in robust sensing
systems that display superior analytical performance. The use of nanomaterials within …

A deep investigation into the structure of carbon dots

KJ Mintz, M Bartoli, M Rovere, Y Zhou… - Carbon, 2021 - Elsevier
Since their discovery, carbon dots (CDs) have been a promising nanomaterial in a variety of
fields including nanomedicine. Despite their potential in this area, there are many obstacles …

Unveiling unconventional luminescence behavior of multicolor carbon dots derived from phenylenediamine

F Yan, J Li, X Zhao, X Gong - The Journal of Physical Chemistry …, 2023 - ACS Publications
Fluorescence regulation of carbon dots (CDs) during their preparation has become a hot
research topic. In this work, multicolor fluorescent CDs with unconventional luminescence …

Inorganic nano-drug delivery systems for crossing the blood–brain barrier: Advances and challenges

Q Tan, S Zhao, T Xu, Q Wang, M Zhang, L Yan… - Coordination Chemistry …, 2023 - Elsevier
The blood–brain barrier (BBB) exists between plasma and brain tissue. It comprises a
capillary wall and glial cells and prevents external substances, including therapeutic agents …

Carbon dots: A future Blood–Brain Barrier penetrating nanomedicine and drug nanocarrier

W Zhang, G Sigdel, KJ Mintz, ES Seven… - International journal …, 2021 - Taylor & Francis
Drug delivery across the blood–brain barrier (BBB) is one of the biggest challenges in
modern medicine due to the BBB's highly semipermeable property that limits most …

Carbon dots as versatile nanoarchitectures for the treatment of neurological disorders and their theranostic applications: A review

M Ashrafizadeh, R Mohammadinejad… - Advances in colloid and …, 2020 - Elsevier
The development of novel methods plays a fundamental role in early diagnosis and
controlling of neurological disorders (NDs). Blood-brain barrier (BBB) is the most …

Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles

Y Qi, L Guo, Y Jiang, Y Shi, H Sui, L Zhao - Drug Delivery, 2020 - Taylor & Francis
It is reported that quercetin (Que) can prevent tau pathology and induce neuroprotection by
improving cognitive and functional symptoms in the treatment of Alzheimer's disease (AD) …

Functionalized nanomaterials capable of crossing the blood–brain barrier

S Zha, H Liu, H Li, H Li, KL Wong, AH All - ACS nano, 2024 - ACS Publications
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …

Progress in drug delivery and diagnostic applications of carbon dots: a systematic review

H Kaurav, D Verma, A Bansal, DN Kapoor… - Frontiers in …, 2023 - frontiersin.org
Carbon dots (CDs), which have particle size of less than 10 nm, are carbon-based
nanomaterials that are used in a wide range of applications in the area of novel drug …