As one of the major approaches in combating the COVID-19 pandemics, the availability of
specific and reliable assays for the SARS-CoV-2 viral genome and its proteins is essential to …

Unsatisfied clinical outcome drives to better understand hepatic carcinogenesis,
microenvironment and escape of immune surveillance in hepatocellular carcinoma (HCC) …

Hedgehog (Hh) signaling is a classic morphogen in controlling embryonic development and
tissue repairing. Aberrant activation of Hh signaling has been well documented in liver …

Background: Hepatic fibrosis is a premalignant lesion, and how injured hepatocytes
transform into malignancy in a fibrotic microenvironment is poorly understood. Senescence …

Biosensors, devices capable of detecting biomolecules or bioactive substances, have
recently become one of the important tools in the fields of bioanalysis and medical …

Hepatocellular carcinoma is currently the most common malignancy of the liver. It typically
occurs due to a series of oncogenic mutations that lead to aberrant cell replication. Most …

Abstract Sonic Hedgehog (SHh) protein is commonly over-expressed in various cancers and
correlates closely to tumor generation, metastasis and drug resistance, and the detection of …

Hedgehog signaling is activated in response to liver injury, and modulates organogenesis.
However, the role of non-canonical hedgehog activation via TGF-β1/SMAD3 in hepatic …

DNA walkers have been widely used to build biosensing systems. However, their moving
efficiency was limited, which has hindered practical applications. Here, we for the first time …

The high expression of Sonic Hedgehog (SHh) is responsible for the known biological
activity of Hedgehog, which closely correlates with cancer metastasis, drug resistance and …